
职称:副教授/博导
学位:博士
电话:15527102466
邮箱:wansm@mail.hzau.edu.cn
政治面貌:中共党员
研究方向:鱼类遗传育种与功能基因组学,重点开展鱼类不同类型肌间刺发生发育机制解析、无肌间刺鱼类新种质创制等
教育经历
2018年02月至2020年09月在萨格勒布大学农学院学习,获理学博士学位;
2014年09月至2019年12月在437437必赢国际网址学习,获农学博士学位;
2010年09月至2014年06月在437437必赢国际网址学习,获学士学位。
主要职历
2022年04月—至今,437437必赢国际网址,副教授;
2020年01月—2022年12月,中国科学院南海海洋研究所,博士后。
科研成果
主持科研项目情况:
1. 国家重点研发计划“海洋农业与淡水渔业科技创新”重点专项课题,鲫肌间刺发育遗传基础和调控机制解析(2023YFD2400301),2023.12-2027.12,640万元,课题负责人;
2. 国家自然科学基金面上项目,刀鲚不同类型肌间刺发育的细胞分化与分子调控异质性研究(32473145),2025.01-2028.12,50万元,项目负责人;
3. 重庆市水产科技创新联盟2025年度“揭榜挂帅”重点创新攻关项目,少/无肌间刺翘嘴鲌新种质创制与隔离保种体系构建(CQFTIU202501-2),2025.01-2025.12,70万元,课题负责人;
4. 江西省重点研发计划课题,江西地方鲫少肌间刺新种质创制与新品系选育(20232BBF60013),2023.07-2026.06,35万元,课题负责人;
5. 2023年度重庆市水产科技创新重点攻关项目,无肌间刺翘嘴鲌新种质创制(COFTIU2024-15),2024.01-2024.12,20万元,课题负责人;
6. 437ccm·必赢国际自主科技创新基金,刀鲚不同类型肌间刺形成的组织细胞学基础研究(510323075),2023.01-2025.12,20万元,项目负责人;
7. 湖北省重点研发计划课题,长江刀鲚生态繁育技术研发(2022BBA008),2022.07-2024.12,20万元,课题负责人;
8. 校企科技合作项目,长江刀鲚养殖驯化试验示范,2022.04-2022.12,20万元,项目负责人;
9. 国家自然科学基金青年科学基金项目,印-太海域克氏海马谱系地理格局与适应性分化研究(42106120),2022.01-2024.12,30万元,项目负责人;
10. 中国博士后科学基金第67批面上项目,scpp1对海马骨板形态发生与矿化的分子调控作用研究(2020M672869),2020.04-2021.12,8万元,项目负责人。
发表学术论文情况:
1. Yu Y, Wan SM*, Zhang SM, Liu JQ, Sun AL, Wang Y, Zhu YF, Gu SX, Gao ZX*, Identification of SNPs and candidate genes associated with growth using GWAS and transcriptome analysis in Coilia nasus. Aquaculture, 2024, 586:740777.
2. Yu Y, Wan SM*, Huang CY, Zhang SM, Sun AL, Liu JQ, Li SY, Zhu YF, Gu SX, Gao ZX*. Combining genome-wide association study and transcriptome analysis to identify molecular markers and genetic basis of population-asynchronous ovarian development in Coilia nasus. Zoological research, 2024, 45(3):491-505.
3. Li SY, Xiong XM, Qiu SY, Shen ZG, He Y, Gao ZX*, Wan SM*. Chromosome-level genome assembly of the yellow-cheek carp Elopichthys bambusa. Scientific data, 2024, 11(1):426.
4. Zhang SM, Xu ZS, Luo LF, Gu SX, Hu Z, Wan SM*, Gao ZX*. Genetic diversity and population structure of Coilia nasus revealed by 2b-RAD sequencing. Biology, 2023, 12(4):600.
5. Xiong XM#, Huang WJ#, Dong Q, Zhang DY, Wan SM, Gao ZX*. Genetic parameter estimates for intermuscular bone trait in grass carp (Ctenopharyngodon idella). Aquaculture, 2023, 563:739011.
6. Qu M#, Zhang YY#, Gao ZX#, Zhang ZX#, Liu YL, Wan SM, Wang X, Yu HY, Zhang HX, Liu YH, Schneider R, Meyer A*, Lin Q*. The genetic basis of the leafy seadragon's unique camouflage morphology and avenues for its efficient conservation derived from habitat modeling. Science China. Life sciences, 2023, 66(6):1213-1230.
7. Dong Q#, Nie CH#, Wu YM, Zhang DY, Wang XD, Tu T, Jin J, Tian ZY, Liu JQ, Xiao ZY, Wan SM, Gao ZX*. Generation of blunt snout bream without intermuscular bones by runx2b gene mutation. Aquaculture, 2023, 567:739263.
8. Wu YM#, Sun AL#, Nie CH, Gao ZX, Wan SM*. Functional differentiation of bmp2a and bmp2b genes in zebrafish. Gene expression patterns, 2022, 46:119288.
9. Nie CH#, Wan SM#, Chen YL#, Huysseune A, Wu YM, Zhou JJ, Hilsdor AWS, Wang WM, Witte PE, Lin Q*, Gao ZX*. Single-cell transcriptomes and runx2b−/− mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National Science Review, 2022, 9:nwac152.
10. Qu M#, Liu YL#, Zhang YH#, Wan SM#, Ravi V#, Qin G#, Jiang H, Wang X, Zhang HX, Zhang B, Gao ZX, Huysseune A, Zhang ZX, Zhang H, Chen ZL, Yu HY, Wu YL, Tang L, Li CY, Zhong J, Ma LM, Wang FL, Zheng HK, Yin JP, Witten PE, Meyer A*, Venkatesh B*, Lin Q*. Seadragon genome analysis provides insights into its phenotype and sex-determination locus. Science Advance, 2021, 7(34):eabg5196.
11. Nie CH#, Wan SM#, Chen YL, Zhu DJ, Wang XD, Dong XR, Gao ZX*. Loss of scleraxis leads to distinct reduction of mineralized intermuscular bone in zebrafish. Aquaculture and Fisheries, 2021, 6:169-177.
12. Li CY#, Olave M#, Hou YL#, Qin G#, Schneider RF#, Gao ZX#, Tu XL, Wang X, Qi FR, Nater A, Kautt AF, Wan SM, Zhang YH, Liu YL, Zhang HX, Zhang B, Zhang H, Qu M, Liu SS, Chen ZY, Zhong J, Zhang H, Meng LF, Wang K, Yin JP, Huang LM, Venkatesh B*, Meyer A*, Lu XM*, Lin Q*. Genome sequences reveal global dispersal routes and suggest convergent genetic adaptations in seahorse evolution. Nature Communications, 2021, 12:1094.
13. Chen YL#, Wan SM#, Li Q, Dong XR, Diao JH, Liao Q, Wang GY, Gao ZX*. Genome-wide integrated analysis revealed functions of lncRNA-miRNA-mRNA interaction in growth of intermuscular bones in Megalobrama amblycephala. Frontiers in Cell and Developmental Biology, 2021, 8:603815.
14. Zhang RR, Wang X*, Wan SM, Ma SB, Lin Q. A new species of Pegasus (Syngnathiformes: Pegasidae) from the South China Sea. Zootaxa, 2020, 4894(4):521-534.
15. Nie CH, Hilsdorf AWS, Wan SM, Gao ZX*. Understanding the development of intermuscular bones in teleost: status and future directions for aquaculture. Reviews in Aquaculture, 2020, 12(2):759-772.
16. Wan SM#, Xiong XM#, Tomljanovic T, Chen YL, Liu H, Treer T, Gao ZX*. Identification and mapping of SNPs associated with number of intermuscular bone in blunt snout bream. Aquaculture, 2019, 507:75-82.
17. Nie CH, Wan SM, Liu YL, Liu H, Wang WM, Gao ZX*. Development of teleost intermuscular bones undergoing intramembranous ossification based on histological-transcriptomic-proteomic data. International journal of molecular sciences, 2019, 20(19):4698.
18. Zhao BW, Zhou LF, Liu YL, Wan SM, Gao ZX*. Evolution of fish Let-7 microRNAs and their expression correlated to growth development in blunt snout bream. International journal of molecular sciences, 2017, 18(3):646.
19. Wan SM, Liu H, Zhao BW, Nie CH, Wang WM, Gao ZX*. Construction of a high-density linkage map and fine mapping of QTLs for growth and gonad related traits in blunt snout bream. Scientific Reports, 2017, 7:46509.
20. Nie CH, Wan SM, Tomljanovic T, Treer T, Hsiao CD, Wang WM, Gao ZX*. Comparative proteomics analysis of teleost intermuscular bones and ribs provides insight into their development. BMC genomics, 2017, 18(1):147.
21. Luo W, Wang WM, Wan SM, Lin Q, Gao ZX*. Assessment of parental contribution to fast- and slow-growth progenies in the blunt snout bream (Megalobrama amblycephala) based on parentage assignment. Aquaculture, 2017, 472:23-29.
22. Zhang WZ, Xiong XM, Zhang XJ, Wan SM, Guan NN, Nie CH, Zhao BW, Hsiao CD, Wang WM, Gao ZX*. Mitochondrial genome variation after hybridization and differences in the first and second generation hybrids of bream fishes. PloS one, 2016, 11(7):e0158915.
23. Wan SM, Zhong J, Nie CH, Gao ZX, Zhang XJ*. The complete mitochondrial genome of the hybrid of Megalobrama amblycephala (♀)×Megalobrama terminalis (♂). Mitochondrial DNA Part A, DNA Mapping, Sequencing, and Analysis, 2016, 27(6):3901-3902.
24. Wan SM, Yi SK, Zhong J, Nie CH, Guan NN, Zhang WZ, Gao ZX*. Dynamic mRNA and miRNA expression analysis in response to intermuscular bone development of blunt snout bream (Megalobrama amblycephala). Scientific Reports, 2016, 6:31050.
25. Lin Q*, Luo W, Wan SM, Gao ZX. De Novo Transcriptome analysis of two seahorse species (Hippocampus erectus and H. mohnikei) and the development of molecular markers for population genetics. PloS one, 2016, 11(4):e0154096.
26. Bao MM, Zhang XJ, Xie CX, Wan SM, Cai LG, Zhou Q*. The complete mitochondrial genome of Schizothorax pseudaksaiensis (Cypriniformes: Cyprinidae). Mitochondrial DNA Part A, DNA Mapping, Sequencing, and Analysis, 2016, 27(2):1385–1386.
27. Zhao HH, Zeng C, Yi SK, Wan SM, Chen BX, Gao ZX*. Leptin genes in blunt snout bream: cloning, phylogeny and expression correlated to gonads development. International .journal of molecular sciences, 2015, 16(11):27609–27624.
28. Wan SM, Yi SK, Zhong J, Nie CH, Guan NN, Chen BX, Gao ZX*. Identification of microRNA for intermuscular bone development in blunt snout bream (Megalobrama amblycephala). International Journal of Molecular Sciences, 2015, 16(5):10686-703.
29. Chen BX, Wan SM, Gao ZX*. The complete mitochondrial genome of the hybrid of Megalobrama skolkovii (♀) × Megalobrama amblycephala (♂). Mitochondrial DNA: The Journal of DNA Mapping, Sequencing, and Analysis, 2015, 27(5):3768-9.
30. 汪 韵, 熊雪梅, 万世明, 高泽霞*. Tent5c基因对斑马鱼肌间刺发育的影响. 水生生物学报, 2024, 48(11): 1934-1942.
31. 廖青, 万世明, 王旭东, 高泽霞*. 鱼类I型与II型胶原蛋白基因系统进化及其在有/无肌间骨代表鱼中的表达比较分析. 水生生物学报, 2021, 45(2): 318-326.
32. 聂春红, 陈祖萱, 戴彩娇, 万世明, 高泽霞*. 不同鱼类肌间骨的骨化模式研究. 水生生物学报, 2018, 42(01):131-137.
33. 万世明, 易少奎, 仲嘉, 王卫民, 蒋恩明, 陈柏湘, 高泽霞*. 团头鲂肌间骨发育的形态学观察. 水生生物学报, 2014. 38(6): 1143-1151.
授权/申请专利情况:
1. 高泽霞,于跃,万世明,张霜萌,汪垚,顾树信. 一种用于刀鲚性别鉴定的特异性分子标记、分子标记组合及其应用,ZL202410682623.5,中国发明专利,2024.12.27.
2. 万世明,孙爱丽,高泽霞,周志娟,张霜萌,郝文鑫,邱思雨. 一种肌间刺钝化增粗鱼类的分子育种方法,CN202411391037.1,中国发明专利,2024.12.10.
3. 高泽霞,万世明,聂春红,孙爱丽,王正银,张霜萌,刘俊岐. 快速获得基因型纯合的无肌间刺草鱼方法,CN202411755446.5,中国发明专利,2023.12.22.
4. 高泽霞,徐子升,罗丽飞,万世明,许柯昕,滕金梦,顾树信. 一种鉴定刀鲚遗传性别的SNP标记及其引物和应用,ZL202210538110.8,中国发明专利,2023.9.8.
5. 高泽霞,聂春红,万世明,陈宇龙,朱德杰. 一段分离的核苷酸序列在无矿化肌间骨斑马鱼构建中的应用,ZL202011115842.3,中国发明专利,2021.9.24.
6. 高泽霞,万世明,聂春红,陈宇龙. 一段分离的核苷酸序列在肌间刺减少的斑马鱼构建中的应用,ZL201911104496.6,中国发明专利,2021.5.7.
7. 高泽霞,聂春红,周琼,魏开建,万世明,王卫民. 一种团头鲂成鱼肌间骨染色的方法及应用,ZL201511003963.8,中国发明专利,2018.4.10.
8. 高泽霞,万世明,易少奎,钟嘉,王卫民. 一种团头鲂肌间骨总RNA提取方法,ZL201310673534.6,中国发明专利,2016.1.20.
9. 万世明,高泽霞,罗伟,赵鸿昊,林强,张艳红,张辉贤. 一种用于鉴别两个海马种群的SSR分子标记方法,ZL201410056237.1,中国发明专利,2015.6.3.
获奖
1. 高泽霞,周莉,万世明,聂春红,甘瑞海,王卫民,桂建芳.《基于基因编辑创制无肌间刺大宗淡水鱼新种质技术》,全国水产技术推广总站-中国水产学会渔业新技术新产品新装备2023年度优秀科技成果。
指导本科生课题情况
1. 李瑷月,苏勋衍。2024年国家级大学生创新创业项目,青鳉椎体小骨发育的细胞分化特征和组织溯源研究(202410504050),2024.04-2025.11,2万元。
2. 邱思雨,李美玖。2023年国家级大学生创新创业项目,angptl7基因在刀鲚多类型肌间刺形成中的调控机制研究(202310504050),2023.05-2025.05,2万元。
3.苏勋衍,柴聪欣,李明轩。2022年省级大学生创新创业项目,刀鲚不同类型肌间刺发育及其组织细胞演化特征研究(S202210504201),2022.05-2024.05,8千元。
备注
欢迎对鱼类遗传育种、鱼类肌间刺等骨骼演化发育机制解析感兴趣的同学加入团队