职称： 副教授

学位： 博士

政治面貌：中共党员

邮箱： huguangfu@mail.hzau.edu.cn

研究方向： 鱼类内分泌学&鱼类育种

教育经历

2010-09 至 2014-12, 香港大学, 鱼类内分泌学, 博士

2007-09 至 2010-06, 437ccm·必赢国际, 鱼类育种, 硕士

2003-09 至 2007-06, 437ccm·必赢国际, 水产养殖, 学士

博士后工作经历

2019-07 至今, 在站, 中国科学院水生生物研究所

科研与学术工作经历

2017-01 至今, 437ccm·必赢国际, 437437必赢国际网址, 副教授、

2015-01 至 2016-12, 437ccm·必赢国际, 437437必赢国际网址, 副研究员

科研工作

1.目前开展的主要科研工作总结

（1）开展鱼类内分泌学研究：

以斑马鱼和经济鱼类为研究对象，开展鱼类内分学研究。1）以斑马鱼为研究模型，开展鱼类生殖和生长内分泌调节机制研究。2）以草鱼、黄鳝、中华鲟等经济鱼类为研究对象，从内分泌学角度解决上述鱼类在生产过程中遇到的性腺发育问题。

（2）开展鱼类基因编辑育种：

以斑马鱼为研究对象，通过基因编辑构建了多个速生、抗病、抗逆的模型。在此基础上，以草鱼、鲤鱼和黄鳝等为对象，通过基因编辑制备速生、抗病且育性可控的经济鱼类新品系。

2.近年承担的相关科研项目

1）中央高校基本科研业务费，2662024SCPY001，营养代谢通过胆囊收缩素介导促进鱼类性腺成熟的作用机制，2024.6-2026.6，30万，主持。

2）中央高校基本科研业务费，2662024FW006，黄鳝大规格苗种培育及成鱼生态养殖技术推广，2024.7-2025.6，8万，主持。

3）科学技术部, 国家重点研发计划，2022YFF1000300, 重要养殖鱼、虾高产和抗病性状形成的分子调控网络研究，2022-12 至 2027-11，60万元，参与。

4）科学技术部, 科技创新2030重大项目，2023ZD0405402，优质速生鱼新品种设计与培育，2023-09至2025-12，60万元, 参与。

5）湖北省农业农村厅, 湖北省支持种业高质量发展资金项目, HBZY2023B009, 名优水产养殖品种良种繁育技术攻关, 2023-09 至 2026-09，28万元, 参与。

6）湖北黄鳝产业技术研究院有限公司，黄鳝速生新品系的选育与推广应用，2024-09至2026-12，10万元，主持。

7）湖北省科技厅, 湖北省自然科学基金（联合基金项目），2023AFD182, VD3调节中华鲟性腺发育的作用机制研究，2023-07 至 2026-06，20万元，参与。

3.发表论文

1）Li HY, Liang HW, Gao XW, Zeng XT, Zheng S, Wang LL, Yuan FM, Xu SH, Yin Z, Hu GF*. Cholecystokinin (CCK) is a mediator between nutritional intake and gonadal development in teleosts. Cells, 2025, 14(2), 78.

2）Gao XW, Ke L, Wang LL, Zheng S, Liu XJ, Hu WH, Tong GB, Li Z, Hu GF*. Low- temperature-induced distruption of reproductive axis and sperm vitality via stress axis in Monopterus albus. Gen Comp Endocrinol, 2024, 114617.

3）Wei Li, Hangyu Li, Qiongyao Hu, Linlin Wang, Zhan Yin, Guangfu Hu*. IGFBP1a is a nutrient deficient response factor that can inhibit fish reproduction through the hypothalamus-pituitary-ovary axis. Biology of Reproduction, 2024,110(4): 761-771.

4）Yunyi Xie, Kan Xiao, Tianyi Cai, Xuetao Shi, Lingling Zhou, Hejun Du, Jing Yang, Guangfu Hu*. Neuropeptides and hormones in hypothalamus-pituitary axis of Chinese sturgeon (Acipenser sinensis). Gen Comp Endocrinol, 2023, 330:114135.

5）Yunyi Xie, Xuetao Shi, Kan Xiao, Lingling Zhou, Tingting Shu, Hejun Du, Jing Yang, Guangfu Hu*. Sequences analysis and pituitary actions of tachykinins in Chinese sturgeon (Acipenser sinensis). Gene, 2023, 879: 147592.

6）Ruixin Du, Xuetao Shi, Feng Chen, Li Wang, Hongwei Liang, Guangfu Hu*. Corticotropin-Releasing Hormone: A Novel Stimulator of Somatolactin in Teleost Pituitary Cells. Cells, 2023, 12(24): 2770.

7）Wei Li, Ruixin Du, Chuanhui Xia, Huiying Zhang, Yunyi Xie, Xiaowen Gao, Yu Ouyang, Zhan Yin, Guangfu Hu*. Novel pituitary actions of GnRH in teleost: the link between reproduction and feeding regulation. Frontiers in Endocrinology, 2022, 13: 982297.

8）Lingling Zhou, Ruibin Yang, Hua Tian, Xiangfeng Qin, Cheng Ye, Xuetao Shi1, Chuanhui Xia, Tianyi Cai, Yunyi Xie, Yongyi Jia, Guangfu Hu*. Sexual dimorphism in Odontobutis sinensis brain-pituitary-gonad axis and liver highlighted by histological and transcriptomic approach. Gene, 2022, 819:146264.

9）Xiaowen Gao, Tianyi Cai, Yongtong Lin, Rui Zhu, Wenxin Hao, Shuming Guo, Guangfu Hu*. The function of glucose metabolism in embryonic diapause of annual killifish. Comp Biochem Physiol Part D Genomics Proteomics, 2022, 42: 100965.

10）Chuanhui Xia, Xiangfeng Qin, Lingling Zhou, Xuetao Shi, Tianyi Cai, Yunyi Xie, Wei Li, Ruixin Du, Yu OuYang, Zhan Yin, Guangfu Hu*. Reproductive regulation of PrRPs in teleost: the link between feeding and reproduction. Frontiers in Endocrinology, 2021, 12: 762826.

11）Shaohua Xu, Lingling Zhou, Shuming Guo, Qiongyao Hu, Xuetao Shi, Chuanhui Xia, Huiying Zhang, Cheng Ye, Yongyi Jia, Guangfu Hu*. Different pituitary action of NK3Ra and NK3Rb in grass carp. Gen Comp Endocrinol, 2021, 313:113829.

12）Xuetao Shi, Cheng Ye, Xiangfeng Qin, Lingling Zhou, Chuanhui Xia, Tianyi Cai, Yunyi Xie, Zhan Yin, Guangfu Hu*. Novel Pituitary Actions of TAC4 Gene Products in Teleost. Int J Mol Sci, 2021, 22(23): 12893.

13）Qiongyao Hu, Qinbo Qin, Shaohua Xu, Lingling Zhou, Chuanhui Xia, Xuetao Shi, Huiying Zhang, Jingyi Jia, Cheng Ye, Zhan Yin, Guangfu Hu*. Pituitary Actions of EGF on Gonadotropins, Growth Hormone, Prolactin and Somatolactins in Grass Carp. Biology, 2020, 9(9): 279.

14）Cheng Ye, Shaohua Xu, Qiongyao Hu, Minqiang Hu, Lingling Zhou, Xiangfeng Qin, Jingyi Jia, Guangfu Hu*. Structure and function analysis of various brain subregions and pituitary in grass carp (Ctenopharyngodon idellus). Comp Biochem Physiol Part D Genomics Proteomics, 2020, 33:100653.

15）Zhang HY, Liu Y, Zhou LL, Xu SH, Ye C, Tian HF, Li Z, Hu GF*. Metabonomic insights into the sperm activation mechanisms in ricefield eel (Monopterus albus). Genes, 2020, 11(11), 1259.

16）Cheng Ye, Shaohua Xu, Qiongyao Hu, Lingling Zhou, Xiangfeng Qin, Jingyi Jia, Guangfu Hu*. Global view of neuropeptides and their receptors in the brain and pituitary of grass carp (Ctenopharyngodon idellus). Aquaculture, 2019, 512: 1-22.

17）Lingling Zhou, Hongwei Liang, Xiaoyun Zhou, Jingyi Jia, Cheng Ye, Qiongyao Hu, Shaohua Xu, Yongning Yu, Guiwei Zou, Guangfu Hu*. Genetic Characteristic and RNA-Seq Analysis in Transparent Mutant of Carp-Goldfish Nucleocytoplasmic Hybrid. Genes, 2019, 10(9): 704.

18）Guangfu Hu*, Mulan He, Wendy K W Ko, Cheng Ye, Qiongyao Hu, Anderson O L Wong. IGFs Potentiate TAC3-induced SLα Expression via Upregulation of TACR3 Expression in Grass Carp Pituitary Cells. Cells, 2019, 8(8): 887.

19）Qiongyao Hu, Shaohua Xu, Cheng Ye, Jingyi Jia, Lingling Zhou, Guangfu Hu*. Novel Pituitary Actions of Epidermal Growth Factor: Receptor Specificity and Signal Transduction for UTS1, EGR1, and MMP13 Regulation by EGF. Int J Mol Sci, 2019, 20(20): 5172.

20）Xiangfeng Qin, Cheng Ye, Xiaoyun Zhou, Jingyi Jia, Shaohua Xu, Qiongyao Hu, Guangfu Hu*. NK3R Mediates the EGF-Induced SLα Secretion and mRNA Expression in Grass Carp Pituitary. Int J Mol Sci, 2018, 20(1): 91.

21）Xiangfeng Qin, Yaqian Xiao, Cheng Ye, Jingyi Jia, Xiangjiang Liu, Hongwei Liang, Guiwei Zou, Guangfu Hu*. Pituitary Action of E2 in Prepubertal Grass Carp: Receptor Specificity and Signal Transduction for Luteinizing Hormone and Follicle-Stimulating Hormone Regulation. Front Endocrinol, 2018, 9: 308.

22）Guangfu Hu*, Mulan He, Wendy K.W. Ko, Anderson O. L. Wong. TAC1 gene products regulate pituitary hormone secretion and gene expression in prepubertal grass carp pituitary cells. Endocrinology, 2017, 158(6): 1776-1797.

23）Xiangjiang Liu, Hongwei Liang, Zhong Li, Yongjun Liang, Cuiyun Lu, Chitao Li, Yumei Chang, Guiwei Zou, Guangfu Hu*. Performances of the hybrid between CyCa nucleocytplasmic hybrid fish and scattered mirror carp in different culture environments. Sci Rep, 2017, 7: 46329.

24）Guangfu Hu*, Mulan He, Anderson On Lam Wong. Novel Functional Role of NK3R Expression in the Potentiating Effects on Somatolactin α Autoregulation in grass carp pituitary cells. Sci Rep, 2016, 6: 36102.

25）Guangfu Hu, Chengyuan Lin, Mulan He, Anderson O L Wong. Neurokinin B and reproductive functions: "KNDy neuron" model in mammals and the emerging story in fish. Gen Comp Endocrinol, 2014 , 208:94-108.

26）Guangfu Hu, Mulan He, Wendy K W Ko, Chengyuan Lin, Anderson O L Wong. Novel pituitary actions of TAC3 gene products in fish model: receptor specificity and signal transduction for prolactin and somatolactin α regulation by neurokinin B (NKB) and NKB-related peptide in carp pituitary cells. Endocrinology, 2014, 155(9): 3582-96.

4.授权发明专利

1）呼光富；秦向锋；刘香江；李忠；叶城；王卫民；肖亚倩；周小云；邹桂伟；一种黄鳝精子超低温冷冻保存液及其冷冻复苏方法，2021-12-07，中国，ZL201710980208.8 （发明专利）

2）呼光富；王丽；刘香江；史雪涛；欧阳雨；谢云轶；肖衎；舒婷婷；杨菁；杜合军；一种竞争型中华鲟促卵泡生成素检测试剂盒及应用，ZL202211184819.9（发明专利）

3）呼光富；陈凤；刘香江；欧阳雨；黄安林；殷战；一种竞争型草鱼泌乳素检测试剂盒及应用，ZL202211185303.6（发明专利）

4）呼光富；刘香江；秦向锋；叶城；黄安林；肖亚倩；魏开建；一种草鱼下丘脑细胞体外培养方法, 2021-05-18，中国，ZL201710980213.9（发明专利）

5）刘香江；欧阳雨；呼光富；史雪涛；谢云轶；肖衎；舒婷婷；杨菁；杜合军；一种竞争型中华鲟促黄体生成素检测试剂盒及应用，中国，ZL202211185246.1（发明专利）

6）刘香江；窦珺；呼光富；欧阳雨；黄安林；殷战；一种竞争型草鱼卵泡刺激素检测试剂盒及应用，中国，ZL202211185349.8（发明专利）

5. 获奖证书及其他社会兼职

1）梁宏伟；邹桂伟；呼光富；姬伟；罗相忠；李忠；刘香江；史则超；程保琳；黄颡鱼种质创新与利用，湖北省人民政府，科技进步三等奖，2018.

社会服务

1）2024年度省级科技特派员，黄鳝速生新品系苗种的选育与推广应用，仙桃，湖北黄鳝产业集团有限公司

2）湖北省黄鳝产业技术研究院特聘研究员

备注：欢迎对探索鱼类生殖和生长调节机制的同学加入