职称 教授

学位 博士

政治面貌 中共党员

邮箱 xuezhen@mail.hzau.edu.cn

研究方向 水产动保与健康养殖

 教育经历 

2005年9月-2008年6月  437437必赢国际网址  博士

2001年9月-2004年6月  437437必赢国际网址  硕士

1995年9月-1999年6月  437437必赢国际网址  学士

 主要职历 

1999年6月-2009年12月    助教，讲师
2010年1月-2010年12月    副教授，硕士生导师
2011年1月-2016年12月    副教授，博士生导师
2012年2月-2013年2月     美国加州大学戴维斯分校，访问学者
2015年1月-2015年2月     法国国家自然历史博物馆，高级访问学者
2017年1月-至今       教授，博士生导师

 科研成果 

一、科研方向

主要科研方向为水产动保与健康养殖。主要研究水产替抗投入品（如中草药、益生菌、噬菌体等）的益生机制、产品开发以及水产健康养殖和水产品质量安全。主持国家自然科学基金、国家重点研发计划、公益性行业科研专项、湖北省杰出青年基金等纵向、横向项目30余项。池塘健康养殖湖北省工程实验室副主任，担任校企合作研发机构华农-天辰研究院院长，注重开展水产产业问题导向的科学研究和技术攻关。

二、教书育人

教授，博士生导师（2011年至今）。曾任437437必赢国际网址水产养殖专业负责人，教学指导委员会委员，获得学校师德先进个人、教学质量一等奖、研究生教书育人奖、十大青年岗位能手等荣誉。已指导博士毕业生12人（含1名留学生）、硕士毕业生53人，已出站博士后2人（含1名留学生）。目前在读全日制博士生4人，硕士生13人。

三、学术研究及社会服务成绩

发表学术论文100余篇，获得授权专利8项，获湖北省科技进步二等奖1项。围绕环境污染物对水生动物及生态安全和水产品质量安全影响、替抗投入品（中草药、益生菌、噬菌体等）益生机制、冷水性鱼类生态养殖等开展了持续深入的研究。在脱贫攻坚和乡村振兴战略产业一线指导渔民开展水产养殖绿色生产被中央电视台、中国教育电视台、中国教育报、农民日报、中国青年报等予以宣传报道，获评湖北省“荆楚好老师”、“最美产业教师”等。

四、部分科研项目情况

1.国家自然科学基金项目-微囊藻毒素microcystin-LR通过调节MAPK信号通路影响斑马鱼卵母细胞减数分裂的机制研究，主持，62万；

2.公益性行业（农业）科研专项-典型化学物污染淡水水产品质量安全综合防治技术方案，华中区任务主持，101万；

3.湖北省杰出青年基金人才项目-微囊藻毒素对鱼类生殖系统致毒机制的研究，主持，20万；

4.鱼虾蟹动保产品研发及工艺研究，企业委托横向课题，主持，100万；

5.水产动物内服保健制剂研发，企业委托横向课题，主持，100万；

6.水产动保内服产品开发合作，企业委托横向课题，主持，50万；

7.开发中药材资源促进水生动物健康养殖，主持，30万。

五、部分学术论文情况

1. Xiong Yinjuan, Huang Xixuan, Li Yuxin, Nie Yukang, Yu Haodong, Shi Yaqi, Xue Jiajie, Ji Zhehui, Rong Keming, Zhang Xuezhen*, 2024, Integrating larval zebrafish model and network pharmacology for screening and identification of edible herbs with therapeutic potential for MAFLD: A promising drug Smilax glabra Roxb. Food Chemistry, 464, 141470.

2.  Li Hongyun, Chen Feifei, Qin Mu, Liao Chenlei, Shi Yaqi, Wu Sihan, Rong Keming, Zhang Xuezhen*,2024, Short-term dietary teprenone improved thermal tolerance and mitigated liver damage caused by heat stress in juvenile largemouth bass (Micropterus salmoides). Comparative Biochemistry and Physiology B- Biochemistry & Molecular Biology. 273, 110984.

3.  Yin Jiaojiao, Cheng Liangyu, Jang Xiaoming, Wang Li, Gao Pan, Zhong Wu, Zhang Xuezhen*, 2024. Metals levels and human health risk assessment in eight commercial fish species collected from a market, Wuhan, China. Frontiers in Sustainable Food Systems. 8, 1346389.

4. Haodong Yu，Ya He ，Mu Qin， Li Wang，Keming Rong，Xuezhen Zhang*. 2024. Dietary creatine promotes creatine reserves, protein deposition, and myofiber hyperplasia in muscle of juvenile largemouth bass (Micropterus salmoides). Aquaculture. 583 (2024) 740591.

5. Feifei Chen, Ziyi Zhang, Li Wang, Haodong Yu , Xuezhen Zhang* , Keming Rong, 2023. Dietary selenium requirement for on-growing grass carp, Ctenopharyngodon idellus. Aquaculture 573 (2023) 739572

6.  Li Wang , Jiaojiao Yin , Chenlei Liao , Rui Cheng , Feifei Chen , Haodong Yu，Xuezhen Zhang*，2023，Selenium deficiency-induced high concentration of reactive oxygen species restricts hypertrophic growth of skeletal muscle in juvenile zebrafish by suppressing TORC1-mediated protein synthesi. British Journal of Nutrition (2023), 130, 1841–1851

7. Jiaojiao Yin, Li Wang, Taotao Huang, Long Wang, Feng Zhang,  Xuezhen Zhang,  A combined survey and exposure study reveals the distribution characteristic of chromium in fish head. Environmental Science and Pollution Research (2023) 30:40630–40640

8. Haodong Yu, Ya He, Jinying Zhang, Ziyi Zhang, Xuezhen Zhang*，2023.  Hepatic transcriptome analysis reveals the metabolic strategies of largemouth bass (Micropterus salmoides) under different dissolved oxygen condition. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics 45: 101032.

9. Rui Cheng, Zhiming Zhang, Chunhua Zhan, Tianlong Qin, Li Wang, Xuezhen Zhang*, 2023.  Environmentally relevant concentrations of selenite trigger reproductive toxicity by affecting oocyte development and promoting larval apoptosis. Environmental Pollution 316 (2023) 120648.

10. Rui Cheng, Jinying Zhang, Ya He, Chenlei Liao, Li Wang, Xuezhen Zhang*, 2022. Parental exposure to waterborne selenite induces transgenerational development toxicity in zebrafish offspring. Chemosphere 303 (2022) 134838.

11. Chenlei Liao, Feng Zhang, Zhenlei Teng, Guirong Zhang, Ying Yang, Pengke Xu, Xixuan Huang, Li Wang, Fan Yang, Zhilong Yang, Xuezhen Zhang*, 2022. Molecular characterization and expression analysis of selenoprotein W gene in rainbow. Biometals. https://doi.org/10.1007/s10534-022-00451-z. 35 (6) , pp.1359-1370

12. Ya He, Haodong Yu, Ziyi Zhang, Jinying Zhang, Shengchao Kang, Xuezhen Zhang*, 2022.   Effects of chronic hypoxia on growth performance, antioxidant capacity and protein turnover of largemouth bass (Micropterus salmoides). Aquaculture 561 (2022) 738673.

13. Zhenlei Teng，Feng Zhang，Li Wang，Long Wang，Taotao Huang，Xuezhen Zhang*，2022. Dietary selenium requirement of triploid rainbow trout (Oncorhynchus mykiss) based on selenium yeast supplementation. Aquaculture Research. 53:3365–3378.

14. Zhang Feng, Teng Zhenlei, Wang Li, Wang, Long, Huang Taotao, Zhang, Xuezhen*. 2022. Dietary Selenium Deficiency and Excess Accelerate Ubiquitin-Mediated Protein Degradation in the Muscle of Rainbow Trout (Oncorhynchus mykiss) via Akt/FoxO3a and NF-kappa B Signaling Pathways. Biological Trace Element Research. 200:1361–1375.

15. Chen Feifei, Wang Li, Zhang Dianfu, LiSai, Zhang Xuezhen*. 2022. Effect of an Established Nutritional Level of Selenium on Energy Metabolism and Gene Expression in the Liver of Rainbow Trout. Biological Trace Element Research. DOI10.1007/s12011-021-02953-2. 200 (8) , pp.3829-3840

16. Yin Jiaojiao， Zhang Feng，Wang Li，Li Sai，Huang Taotao，Zhang Xuezhen*. 2021. A kinetic study on accumulation and depuration of hexavalent chromium in crucian carp (Carassius auratus) reveals the potential health risk of fish head consumption. Food Control. DOI 10.1016/j.foodcont.2021.108291. Food Control 130 (2021) 108291.

17. Li Xiuling, Wang Zhengjun, Bai Ming, Chen Zhehua, Gu Gan, Li Xi, Hu Changwei, Zhang Xuezhen*. 2021. Effects of polystyrene microplastics on copper toxicity to the protozoan Euglena gracilis: emphasis on different evaluation methods, photosynthesis, and metal accumulation. Environmental Science and Pollution Research. DOI 10.1007/s11356-021-17545-9. 29 (16) , pp.23461-23473

18. Huang Xixuan, Hegazy Abeer M, ZhangXuezhen*. 2021. Swimming exercise as potential measure to improve flesh quality of cultivable fish: A review. Aquaculture Research. 52(12) 5978-5989. DOI 10.1111/are.15510.

19. Wang Li, YinJiaojiao, Zhang Feng, Yu Haodong, Chen Feifei, Zhang Ziyi, Zhang, Xuezhen*. 2021. Selenium Status Affects Hypertrophic Growth of Skeletal Muscle in Growing Zebrafish by Mediating Protein Turnover.The Journal of nutrition. 151(7). 1791-1801. DOI: 10.1093/jn/nxab082.

20.  Wang, Li; Wang, Long; Zhang, Dianfu; Li, Sai; Yin, Jiaojiao; Xu, Zhen; Zhang, Xuezhen*， 2020. Effect of dietary selenium on postprandial protein deposition in the muscle of juvenile rainbow trout (Oncorhynchus mykiss). The British journal of nutrition. 125(7)721-731, DOI:10.1017/S000711452000313X.

21. Yin, Jiaojiao, Wang, Li, Wang Long, Huang Taotao, Zhang, Xuezhen*. 2021. Pretreatment with selenium prevented the accumulation of hexavalent chromium in rainbow trout (Oncorhynchus mykiss) and reduced the potential health risk of fish consumption. Food Control. 122, 107817.

22. Yin, Jiaojiao, Wang, Li, Liu, Qi, Li, Sai, Li, Jian, Zhang, Xuezhen*. 2020. Metal concentrations in fish from nine lakes of Anhui Province and the health risk assessment. Environmental Science and Pollution Research. 27(16):20117-20124.

23. Yin, Jiaojiao; Wang, Li; Li, Sai; Chen, Feifei; Hegazy, Abeer M; Zhang, Xuezhen*. 2020. Accumulation and depuration of dissolved hexavalent chromium and effects on the antioxidant response in bighead carp (Aristichthys nobilis). Environmental Toxicology and Pharmacology. 80:103465. DOI:10.1016/j.etap.2020.103465.

24. Wang, Li，Zhang, Dianfu，Li, Sai，Wang, Long，Yin, Jiaojiao，Xu, Zhen， Zhang Xuezhen*, 2020. Dietary Selenium Promotes Somatic Growth of Rainbow Trout (Oncorhynchus mykiss) by Accelerating the Hypertrophic Growth of White Muscle. Biological Tracement Research. DOI: 10.1007/s12011-020-02282-w

25. Chen, Yuanyuan, Yin, Jiaojiao, Wei, Jin, Zhang, Xuezhen*. 2020. FurA-Dependent Microcystin Synthesis under Copper Stress in Microcystis aeruginosa. Microorganisms. DOI: 10.3390/microorganisms8060832

26. Yin, Jiaojiao, Wang, Li, Liu, Qi, Li, Sai, Li, Jian, Zhang, Xuezhen*. 2020. Potential Human Health Risks of Organochlorine Pesticides (OCPs) and Polychlorinated Biphenyls (PCBs) Associated with Fish Consumption in Anhui Province, China. Bulletin of Environmental Contamination and Toxicology.  104（6）：840-845.

27. Zhan, Chunhua, Zhang, Feng, Liu, Wanjing, Zhang Xuezhen*. 2020. Microcystin-LR promotes zebrafish (Danio rerio) oocyte (in vivo) maturation by activating ERK1/2-MPF signaling pathways, and cAMP is involved in this process. Environmental Pollution. 259 (2020) 113843. DOI: 10.1016/j.envpol.2019.113843.

28. Zhan, Chunhua，Liu, Wanjing，Zhang, Feng，Zhang, Xuezhen*， 2020. Microcystin-LR triggers different endoplasmic reticulum stress pathways in the liver, ovary, and offspring of zebrafish (Danio rerio). Journal of Hazardous Materials. 386 (2020) 121939. https://doi.org/10.1016/j.jhazmat.2019.121939

29.  Wanjing Liu, Chunhua Zhan, Tongzhou Zhang, Xuezhen Zhang*. 2019. Microcystin-LR influences the in vitro oocyte maturation of zebrafish by activating the MAPK pathway. Aquatic Toxicology 215, doi:105261.

30.  Kawan A, Zhang T, Liu W, Mukhtar H, Zhan C, Zhang X. 2019. Recovery of reproductive function of female zebrafish from the toxic effects of microcystin-LR exposure. Aquatic Toxicology, 214, doi:105240.

31.  Jiaojiao Yin, Li Wang, Yuanyuan Chen, Dianfu Zhang, Abeer M. Hegazy, Xuezhen Zhang*.2019. A comparison of accumulation and depuration effect of dissolved hexavalent chromium (Cr6+) in head and muscle of bighead carp (Aristichthys nobilis) and assessment of the potential health risk for consumers.  Food Chemistry 286 (2019) 388–394

32.  Chunhua Zhan, Wanjian Liu, Abeer M.Hegazy, Tongzhou Zhang, Atufa Kawan, Xuezhen Zhang* 2019. Explorations of the optimal method for isolating oocytes from zebrafish (Danio rerio) ovary. Journal of Experimental Zoology Part B-Molecular And Developmental Evolution. 330,417–426.

33.  JianLi，Chuanyue Chen，TongzhouZhang，Wanjing Liu，Li Wang，Yuanyuan Chen，LeiWu，Abeer M.Hegazy，El-Sayed A.F，XuezhenZhang*. 2019. Evaluation of microcystin-LR absorption using an in vivo intestine model and its effect on zebrafish intestine. Aquatic Toxicology. 206,186-194.

34.   Xia, Hu, Son, Ting, Wang, Li, Jiang, Liangsen, Zhou, Qiting, Wang, Weimin, Liu, Liangguo, Yang, Pinhong, Zhang, Xuezhen*. 2018. Effects of dietary toxic cyanobacteria and ammonia exposure on immune function of blunt snout bream (Megalabrama amblycephala). Fish &Shellfish Immunology, 78 , 383-391.

35.  Wang, Li, Zhang, Xuezhen*, Wu, Lei, Liu, Qi, Zhang, Dianfu, Yin, Jiaojiao. 2018. Expression of selenoprotein genes in muscle is crucial for the growth of rainbow trout (Oncorhynchus mykiss) fed diets supplemented with selenium yeast. Aquaculture. 492,82-90.

36. Wang Li, Wu Lei, Liu Qi, Zhang Dianfu, Yin Jiaojiao, Xu Zhen, Zhang Xuezhen*. Improvement of flesh quality in rainbow trout (Oncorhynchus mykiss) fed supranutritional dietary selenium yeast is associated with the inhibited muscle protein degradation. Aquaculture Nutrition. 24(4)1351-1360.

37. Yin, Jiaojiao, Liu, Qi, Wang, Li, Li, Jian, Li, Sai, Zhang, Xuezhen*. 2018. The distribution and risk assessment of heavy metals in water, sediments, and fish of Chaohu Lake, China. Envionmental Earth Sciences. 77(3)97.

38. Li, Jian, Hu, Jun, Wu, Kang, Chen, Yuanyuan, Wang, Li, Zhang, Xuezhen*. 2017. Analysis of microbiota in rhizosphere, water and gut of grass carp (Ctenopharyngodon idella) in ponds treated with artificial floating beds. Water and Environment Journal. 31(4) ,572-577.

39. Wang, Li, Chen, Chuanyue, Liu, Wanjing, Xia, Hu, Li, Jian, Zhang, Xuezhen*. 2017. Effects of toxic cyanobacteria and ammonia on flesh quality of blunt snout bream (Megalobramaamblycephala).Journal of the Sciece of Food and Agriculture. 97(4) 1200-1206.

40. Wang Li, Li Jian, Jin Jienan, Zhu Fen , Roffeis M, Zhang Xuezhen.2017. A comprehensive evaluation of replacing fishmeal with housefly (Musca domestica) maggot meal in the diet of Nile tilapia (Oreochromis niloticus): growth performance, flesh quality, innate immunity and water environment. Aquaculture Nutrition, 23,983-993.

41. Yuanyuan Chen, Jian Li, Jin Wei, Atufa Kawan, Li Wang, Xuezhen Zhang* 2017. Vitamin C modulates Microcystis aeruginosa death and toxin releaseby induced Fenton reaction. Journal of Hazardous Materials.321, 888-895.

42. Chen, Chuanyue; Liu, Wanjing; Wang, Li; Li, Jian; Chen, Yuanyuan; Jin, Jienan; Kawan, Atufa; Zhang, Xuezhen* 2016. Pathological damage and immunomodulatory effects of zebrafish exposed to microcystin-LR. Toxicon. 118,13-20.

43. Xia, Hu，Liu, Wanjing，Wu, Kang，Wang, Weimin，Zhang, Xuezhen*.2016. sIgZ exhibited maternal transmission in embryonic development and played a prominent role in mucosal immune response of Megalabrama amblycephala. Fish & Shellfish Immunology. 54, 107-117.

44. Hu, Jun, Ran, Chao, He, Suxu, Cao, Yanan, Yao, Bin, Ye, Yuantu*, Zhang Xuezhen*, Zhou, Zhigang*. 2016. Dietary microbial phytase exerts mixed effects on the gut health of tilapia: a possible reason for the null effect on growth promotion. British Journal of Nutrition. 11:1958-1966.

45.  Liu Wanjing, Chen Chuanyue, Chen Liang, Wang Li, Li Jian, Chen Yuanyuan, Jin Jienan, Kawan Atufa, Zhang Xuezhen*. 2016. Sex-dependent effects of microcystin-LR on hypothalamicpituitary-gonad axis and gametogenesis of adult zebrafish. Scientific Reports | 6:22819 | DOI: 10.1038/srep22819

46. Liang Hualei, Zhou Wenshan, Zhang Yulei, Qiao Qin, Zhang Xuezhen *. 2015. Are fish fed with cyanobacteria safe, nutritious and delicious? A laboratory study.  Scientific Reports | 5:15166 | DOI: 10.1038/srep15166.

47. Xiao Huang, Liang Chen, Wanjing Liu, Qin Qiao, Kang Wu, Jing Wen,Cuihong Huang, Rong Tang, Xuezhen Zhang*. 2015. Involvement of oxidative stress and cytoskeletal disruption inmicrocystin-induced apoptosis in CIK cells. Aquatic Toxicology. 165 (2015) 41–50.

48.  Liu, Wanjing; Qiao, Qin; Chen, Yuanyuan; Wu, Kang; Zhang, Xuezhen*. 2014. Microcystin-LR exposure to adult zebrafish (Danio rerio) leads to growth inhibition and immune dysfunction in F1 offspring, a parental transmission effect of toxicity. Aquatic toxicology 155,360-367.

49. Xia, Hu; Wu, Kang; Liu, Wanjing; Gul, Yasmeen; Wang, Weimin; Zhang, Xuezhen* . 2014. Molecular cloning and expression analysis of immunoglobulin M heavy chain gene of blunt snout bream (Megalobrama amblycephala). Fish & Shellfish Immunology 40,129-135.

50. Qin Qiao, Wanjing Liu, Kang Wu, Ting Song, Jun Hu, Xiao Huang, Jing Wen, Liang Chen, Xuezhen Zhang*. 2013. Female zebrafish (Danio rerio) are more vulnerable than males to microcystin-LR exposure, without exhibiting estrogenic effects. Aquatic Toxicology 142-143, 272-282.

51.  Zhou Wenshan, Zhang Xuezhen*, Xie Ping, Liang Hualei, Zhang Xin. 2013.The suppression of hematopoiesis function in Balb/c mice induced by prolonged exposure of microcystin-LR. Toxicology Letters. 219, 194–201.

52. Chen L, Zhang X*, Zhou W, Qiao Q, Liang H, Li G, Wang J, Cai F. 2013.The Interactive Effects of Cytoskeleton Disruption and Mitochondria Dysfunction Lead to Reproductive Toxicity Induced by Microcystin-LR. PLoS ONE 8(1): e53949. doi:10.1371/journal.pone.0053949.

53. Qiao Q， Liang HL， Zhang XZ*. 2013. Effect of cyanobacteria on immune function of crucian carp (Carassius auratus) via chronic exposure in diet.  Chemosphere, 90:1167-1176.

54. Xin Zhang, Ping Xie*, Xuezhen Zhang*, Wenshan Zhou, Sujuan Zhao, Yanyan Zhao,Yan Cai. 2013. Toxic effects of microcystin-LR on the HepG2 cell line under hypoxic and normoxic conditions. Journal of Applied Toxicology. 33,1180-1186.

55. Wei Ji, Hualei Liang, Wenshan Zhou and Xuezhen Zhang*. 2013. Apoptotic responses of zebrafish (Danio rerio) after exposure with microcystin-LR under different ambient temperatures. Journal of Applied Toxicology. 33, 799-806.